diff --git a/spec/compiler/codegen/target_annotation_spec.cr b/spec/compiler/codegen/target_annotation_spec.cr
new file mode 100644
index 000000000000..6376b412aca1
--- /dev/null
+++ b/spec/compiler/codegen/target_annotation_spec.cr
@@ -0,0 +1,50 @@
+require "../spec_helper"
+
+describe "Code gen: TargetFeature annotation" do
+  it "can target optional CPU features" do
+    {% if compare_versions(Crystal::LLVM_VERSION, "13.0.0") < 0 %} pending! "requires LLVM 13+" {% end %}
+
+    compile(<<-CRYSTAL, target: "aarch64-darwin")
+      @[TargetFeature("+sve,+sve2")]
+      def sve2_smoke_test : Nil
+        asm("ext z0.b, { z1.b, z2.b }, #0" :::: "volatile")
+        nil
+      end
+
+      sve2_smoke_test
+      CRYSTAL
+  end
+
+  it "can optimize code for a specific CPU" do
+    {% if compare_versions(Crystal::LLVM_VERSION, "13.0.0") < 0 %} pending! "requires LLVM 13+" {% end %}
+
+    # unlike the ARM backend, the X86 backend doesn't validate assembly
+    # instructions, but the LLVM intrinsics are validated so we use one
+    compile(<<-CRYSTAL, target: "x86_64-linux-gnu")
+      lib LibIntrinsics
+        fun x86_avx_vzeroall = "llvm.x86.avx.vzeroall"
+      end
+
+      @[TargetFeature(cpu: "x86-64-v3")]
+      def x86_vzeroall : Nil
+        LibIntrinsics.x86_avx_vzeroall
+      end
+
+      x86_vzeroall
+      CRYSTAL
+  end
+
+  it "can target optional CPU features and optimize code for a specific CPU" do
+    {% if compare_versions(Crystal::LLVM_VERSION, "13.0.0") < 0 %} pending! "requires LLVM 13+" {% end %}
+
+    compile(<<-CRYSTAL, target: "aarch64-darwin")
+      @[TargetFeature("+sve,+sve2", cpu: "apple-m1")]
+      def sve2_smoke_test : Nil
+        asm("ext z0.b, { z1.b, z2.b }, #0" :::: "volatile")
+        nil
+      end
+
+      sve2_smoke_test
+      CRYSTAL
+  end
+end
diff --git a/spec/compiler/semantic/target_annotation_spec.cr b/spec/compiler/semantic/target_annotation_spec.cr
new file mode 100644
index 000000000000..7581a356bf22
--- /dev/null
+++ b/spec/compiler/semantic/target_annotation_spec.cr
@@ -0,0 +1,63 @@
+require "../spec_helper"
+
+describe "Semantic: TargetFeature annotation" do
+  it "errors if invalid argument provided" do
+    assert_error <<-CRYSTAL, "no argument named 'invalid', expected 'cpu'"
+      @[TargetFeature(invalid: "lorem ipsum")]
+      def foo
+      end
+      CRYSTAL
+  end
+
+  it "errors if invalid cpu argument type provided" do
+    assert_error <<-CRYSTAL, "expected argument 'cpu' to be String"
+      @[TargetFeature(cpu: 3)]
+      def foo
+      end
+      CRYSTAL
+  end
+
+  it "errors if invalid cpu argument type provided and feature provided" do
+    assert_error <<-CRYSTAL, "expected argument 'cpu' to be String"
+      @[TargetFeature("+sve", cpu: 4)]
+      def foo
+      end
+      CRYSTAL
+  end
+
+  it "errors if invalid feature argument type provided" do
+    assert_error <<-CRYSTAL, "expected argument #1 to 'TargetFeature' to be String"
+      @[TargetFeature(3)]
+      def foo
+      end
+      CRYSTAL
+  end
+
+  it "errors if invalid feature argument type provided and cpu provided" do
+    assert_error <<-CRYSTAL, "expected argument #1 to 'TargetFeature' to be String"
+      @[TargetFeature(3, cpu: "apple-m1")]
+      def foo
+      end
+      CRYSTAL
+  end
+
+  it "errors if wrong number of arguments provided" do
+    assert_error <<-CRYSTAL, "wrong number of arguments for TargetFeature (given 2, expected 0..1)"
+      @[TargetFeature("+sve", "+sve2")]
+      def foo
+      end
+      CRYSTAL
+  end
+
+  it "can target a specific LLVM supported feature" do
+    assert_type(<<-CRYSTAL) { int32 }
+      # This feature is available on all platforms
+      @[TargetFeature("+strict-align")]
+      def strict_align(input : Int32) : Int32
+        input
+      end
+
+      strict_align(1)
+      CRYSTAL
+  end
+end
diff --git a/src/compiler/crystal/codegen/fun.cr b/src/compiler/crystal/codegen/fun.cr
index b3d122bf8f92..4e0943047fad 100644
--- a/src/compiler/crystal/codegen/fun.cr
+++ b/src/compiler/crystal/codegen/fun.cr
@@ -451,16 +451,25 @@ class Crystal::CodeGenVisitor
     context.fun = typed_fun.func
     context.fun_type = typed_fun.type
 
-    if @debug.variables?
+    optimize_none = @debug.variables?
+    features = target_def.target_features
+    cpu = target_def.target_cpu
+
+    if optimize_none || features || cpu
+      # Make it a hard boundary, disabling inlining
       context.fun.add_attribute LLVM::Attribute::NoInline
-      context.fun.add_attribute LLVM::Attribute::OptimizeNone
+
+      context.fun.add_attribute LLVM::Attribute::OptimizeNone if optimize_none
+      context.fun.add_target_dependent_attribute("target-features", features) if features
+      context.fun.add_target_dependent_attribute("target-cpu", cpu) if cpu
     else
       context.fun.add_attribute LLVM::Attribute::AlwaysInline if target_def.always_inline?
+      context.fun.add_attribute LLVM::Attribute::NoInline if target_def.no_inline?
     end
+
     context.fun.add_attribute LLVM::Attribute::ReturnsTwice if target_def.returns_twice?
     context.fun.add_attribute LLVM::Attribute::Naked if target_def.naked?
     context.fun.add_attribute LLVM::Attribute::NoReturn if target_def.no_returns?
-    context.fun.add_attribute LLVM::Attribute::NoInline if target_def.no_inline?
   end
 
   def setup_closure_vars(target_def, closure_vars, context, closure_type, closure_ptr)
diff --git a/src/compiler/crystal/program.cr b/src/compiler/crystal/program.cr
index 3e4e2ab6fb09..f1afb2fc6ebf 100644
--- a/src/compiler/crystal/program.cr
+++ b/src/compiler/crystal/program.cr
@@ -279,6 +279,7 @@ module Crystal
       types["ThreadLocal"] = @thread_local_annotation = AnnotationType.new self, self, "ThreadLocal"
       types["Deprecated"] = @deprecated_annotation = AnnotationType.new self, self, "Deprecated"
       types["Experimental"] = @experimental_annotation = AnnotationType.new self, self, "Experimental"
+      types["TargetFeature"] = @target_feature_annotation = AnnotationType.new self, self, "TargetFeature"
 
       define_crystal_constants
 
@@ -562,7 +563,7 @@ module Crystal
     {% for name in %w(object no_return value number reference void nil bool char int int8 int16 int32 int64 int128
                      uint8 uint16 uint32 uint64 uint128 float float32 float64 string symbol pointer enumerable indexable
                      array static_array exception tuple named_tuple proc union enum range slice regex crystal
-                     packed_annotation thread_local_annotation no_inline_annotation
+                     packed_annotation thread_local_annotation no_inline_annotation target_feature_annotation
                      always_inline_annotation naked_annotation returns_twice_annotation
                      raises_annotation primitive_annotation call_convention_annotation
                      flags_annotation link_annotation extern_annotation deprecated_annotation experimental_annotation) %}
diff --git a/src/compiler/crystal/semantic/ast.cr b/src/compiler/crystal/semantic/ast.cr
index ca5905ef223e..fedeae5f3fd5 100644
--- a/src/compiler/crystal/semantic/ast.cr
+++ b/src/compiler/crystal/semantic/ast.cr
@@ -159,6 +159,12 @@ module Crystal
     # `true` if this def has the `@[ReturnsTwice]` annotation
     property? returns_twice = false
 
+    # Set to the value of the `@[TargetFeature("+sve,+sve2")]` annotation
+    property target_features : String? = nil
+
+    # Set to the value of the `@[TargetFeature(cpu: "apple-m4")]` annotation
+    property target_cpu : String? = nil
+
     # `true` if this def has the `@[Naked]` annotation
     property? naked = false
 
@@ -222,6 +228,8 @@ module Crystal
       a_def.no_inline = no_inline?
       a_def.always_inline = always_inline?
       a_def.returns_twice = returns_twice?
+      a_def.target_features = target_features
+      a_def.target_cpu = target_cpu
       a_def.naked = naked?
       a_def.annotations = annotations
       a_def.new = new?
diff --git a/src/compiler/crystal/semantic/top_level_visitor.cr b/src/compiler/crystal/semantic/top_level_visitor.cr
index 17a29ee2ba93..814242ac8b70 100644
--- a/src/compiler/crystal/semantic/top_level_visitor.cr
+++ b/src/compiler/crystal/semantic/top_level_visitor.cr
@@ -1258,6 +1258,24 @@ class Crystal::TopLevelVisitor < Crystal::SemanticVisitor
         node.returns_twice = true
       when @program.raises_annotation
         node.raises = true
+      when @program.target_feature_annotation
+        ann.named_args.try &.each do |named_arg|
+          case named_arg.name
+          when "cpu"
+            cpu_value = named_arg.value
+            named_arg.raise "expected argument 'cpu' to be String" unless cpu_value.is_a?(StringLiteral)
+            node.target_cpu = cpu_value.value
+          else
+            named_arg.raise "no argument named '#{named_arg.name}', expected 'cpu'"
+          end
+        end
+
+        if ann.args.size > 0
+          ann.raise "wrong number of arguments for TargetFeature (given #{ann.args.size}, expected 0..1)" if ann.args.size > 1
+          features_value = ann.args[0]
+          ann.raise "expected argument #1 to 'TargetFeature' to be String" unless features_value.is_a?(StringLiteral)
+          node.target_features = features_value.value
+        end
       else
         yield annotation_type, ann
       end