diff --git a/tests/disabled/reflect/run/primitive-sigs-2-new.check b/tests/run/primitive-sigs-2-new.check
similarity index 60%
rename from tests/disabled/reflect/run/primitive-sigs-2-new.check
rename to tests/run/primitive-sigs-2-new.check
index 59d864947c00..64c958040946 100644
--- a/tests/disabled/reflect/run/primitive-sigs-2-new.check
+++ b/tests/run/primitive-sigs-2-new.check
@@ -1,6 +1,9 @@
 T<java.lang.Object>
 List(A, char, class java.lang.Object)
 a
+private static final float Arr.arr3$$anonfun$1(float[])
+private static final java.lang.Object Arr.arr4$$anonfun$1(java.lang.Object)
+private static java.lang.Object Arr.$deserializeLambda$(java.lang.invoke.SerializedLambda)
 public <T> java.lang.Object Arr.arr4(java.lang.Object[],scala.reflect.ClassTag<T>)
 public float[] Arr.arr3(float[][])
 public scala.collection.immutable.List<java.lang.Character> Arr.arr2(java.lang.Character[])
diff --git a/tests/disabled/reflect/run/primitive-sigs-2-new.flags b/tests/run/primitive-sigs-2-new.flags
similarity index 100%
rename from tests/disabled/reflect/run/primitive-sigs-2-new.flags
rename to tests/run/primitive-sigs-2-new.flags
diff --git a/tests/disabled/reflect/run/primitive-sigs-2-new.scala b/tests/run/primitive-sigs-2-new.scala
similarity index 92%
rename from tests/disabled/reflect/run/primitive-sigs-2-new.scala
rename to tests/run/primitive-sigs-2-new.scala
index 1f39667b18f1..3de1f8ec5b42 100644
--- a/tests/disabled/reflect/run/primitive-sigs-2-new.scala
+++ b/tests/run/primitive-sigs-2-new.scala
@@ -1,3 +1,5 @@
+// scalajs: --skip
+// (JVM-only, generic signatures)
 
 import scala.language.{ postfixOps }
 import scala.reflect.{ClassTag, classTag}
@@ -28,7 +30,7 @@ object Test {
   def main(args: Array[String]): Unit = {
     println(c2.getGenericInterfaces.map(_.toString).sorted mkString " ")
     println(c1m ++ c2m sorted)
-    println(new C f)
+    println((new C()).f())
     c3m.sorted foreach println
   }
 }
diff --git a/tests/disabled/reflect/run/primitive-sigs-2-old.check b/tests/run/primitive-sigs-2-old.check
similarity index 60%
rename from tests/disabled/reflect/run/primitive-sigs-2-old.check
rename to tests/run/primitive-sigs-2-old.check
index feb06195256f..c7a472a542cf 100644
--- a/tests/disabled/reflect/run/primitive-sigs-2-old.check
+++ b/tests/run/primitive-sigs-2-old.check
@@ -1,6 +1,9 @@
 T<java.lang.Object>
 List(A, char, class java.lang.Object)
 a
+private static final float Arr.arr3$$anonfun$1(float[])
+private static final java.lang.Object Arr.arr4$$anonfun$1(java.lang.Object)
+private static java.lang.Object Arr.$deserializeLambda$(java.lang.invoke.SerializedLambda)
 public <T> java.lang.Object Arr.arr4(java.lang.Object[],scala.reflect.Manifest<T>)
 public float[] Arr.arr3(float[][])
 public scala.collection.immutable.List<java.lang.Character> Arr.arr2(java.lang.Character[])
diff --git a/tests/disabled/reflect/run/primitive-sigs-2-old.flags b/tests/run/primitive-sigs-2-old.flags
similarity index 100%
rename from tests/disabled/reflect/run/primitive-sigs-2-old.flags
rename to tests/run/primitive-sigs-2-old.flags
diff --git a/tests/disabled/reflect/run/primitive-sigs-2-old.scala b/tests/run/primitive-sigs-2-old.scala
similarity index 94%
rename from tests/disabled/reflect/run/primitive-sigs-2-old.scala
rename to tests/run/primitive-sigs-2-old.scala
index 16fe5ae55563..3e00fda690b1 100644
--- a/tests/disabled/reflect/run/primitive-sigs-2-old.scala
+++ b/tests/run/primitive-sigs-2-old.scala
@@ -1,3 +1,5 @@
+// scalajs: --skip
+// (JVM-only, generic signatures)
 
 import scala.language.{ postfixOps }
 import java.{ lang => jl }
@@ -35,7 +37,7 @@ object Test {
   def main(args: Array[String]): Unit = {
     println(c2.getGenericInterfaces.map(_.toString).sorted mkString " ")
     println(c1m ++ c2m sorted)
-    println(new C f)
+    println((new C()).f())
     c3m.sorted foreach println
   }
 }
diff --git a/tests/run/t11321.check b/tests/run/t11321.check
new file mode 100644
index 000000000000..9f0979ba1dab
--- /dev/null
+++ b/tests/run/t11321.check
@@ -0,0 +1,3 @@
+t11321.V: scala.Option<t11321.V>
+t11321.U: scala.Option<t11321.U>
+t11321.W: scala.Option<t11321.W<scala.Function1<java.lang.Object, java.lang.String>>>
diff --git a/tests/run/t11321.scala b/tests/run/t11321.scala
new file mode 100644
index 000000000000..8838dd862334
--- /dev/null
+++ b/tests/run/t11321.scala
@@ -0,0 +1,29 @@
+// scalajs: --skip
+// (JVM-only, generic signatures)
+
+package t11321 {
+  final class V(val x: Int) extends AnyVal
+  object V { def get: Option[V] = null }
+
+  final class U(val y: String) extends AnyVal
+  object U { def get: Option[U] = null }
+
+  final class W[T](val z: T) extends AnyVal
+  object W { def get: Option[W[Int => String]] = null }
+}
+
+
+object Test extends App {
+  def check[T](implicit tt: reflect.ClassTag[T]): Unit = {
+    val companion = tt.runtimeClass.getClassLoader.loadClass(tt.runtimeClass.getName + '$')
+    val get = companion.getMethod("get")
+    assert(get.getReturnType == classOf[Option[_]])
+    println(s"${tt.runtimeClass.getName}: ${get.getGenericReturnType}")
+  }
+
+  import t11321._
+
+  check[V]
+  check[U]
+  check[W[_]]
+}
diff --git a/tests/run/t11321b.check b/tests/run/t11321b.check
new file mode 100644
index 000000000000..e008cea3575a
--- /dev/null
+++ b/tests/run/t11321b.check
@@ -0,0 +1,2 @@
+minnow
+class java.lang.String
diff --git a/tests/run/t11321b/Foo_1.scala b/tests/run/t11321b/Foo_1.scala
new file mode 100644
index 000000000000..21dfbb226644
--- /dev/null
+++ b/tests/run/t11321b/Foo_1.scala
@@ -0,0 +1,7 @@
+// scalajs: --skip
+// (JVM-only, generic signatures)
+
+package t11321
+
+class X(val x: String) extends AnyVal
+class Foo { def b = Option(new X("minnow")); def get = b.get }
diff --git a/tests/run/t11321b/Test_2.java b/tests/run/t11321b/Test_2.java
new file mode 100644
index 000000000000..67de3c58089b
--- /dev/null
+++ b/tests/run/t11321b/Test_2.java
@@ -0,0 +1,9 @@
+package t11321;
+
+public class Test_2 {
+    public static void main(String ...args) {
+        scala.Option<X> b = new Foo().b();
+        System.out.println(b.get().x());
+        System.out.println(b.get().x().getClass());
+    }
+}
diff --git a/tests/run/t11321b/Test_3.scala b/tests/run/t11321b/Test_3.scala
new file mode 100644
index 000000000000..3eecd2a76cd5
--- /dev/null
+++ b/tests/run/t11321b/Test_3.scala
@@ -0,0 +1,5 @@
+import t11321.*
+
+object Test:
+  def main(args: Array[String]): Unit =
+    Test_2.main()
diff --git a/tests/run/t1461.scala b/tests/run/t1461.scala
new file mode 100644
index 000000000000..74db416f8ae0
--- /dev/null
+++ b/tests/run/t1461.scala
@@ -0,0 +1,19 @@
+// scalajs: --skip
+// (JVM-only, generic signatures)
+
+object Test {
+  def main(args: Array[String]): Unit = {
+    val jl = classOf[Foo].getMethod("jl", classOf[Baz[_]])
+    jl.getGenericParameterTypes // works fine
+
+    val l = classOf[Foo].getMethod("l", classOf[Baz[_]])
+    l.getGenericParameterTypes // works fine
+  }
+}
+
+class Baz[T]
+
+class Foo {
+  def l(b: Baz[Long]): Unit = { }
+  def jl(b: Baz[java.lang.Long]): Unit = { }
+}
diff --git a/tests/disabled/reflect/run/t6344.check b/tests/run/t6344.check
similarity index 75%
rename from tests/disabled/reflect/run/t6344.check
rename to tests/run/t6344.check
index 8d9adac849d4..07766a3fec45 100644
--- a/tests/disabled/reflect/run/t6344.check
+++ b/tests/run/t6344.check
@@ -2,9 +2,9 @@ C0
 public int C0.v1(int)
 public <A> int C0.v1(int)
 public int C0.v3()
-public <A> int C0.v3()
+public int C0.v3()
 public int C0.v4(int,scala.collection.immutable.List)
-public <A> int C0.v4(int,scala.collection.immutable.List<Val<A>>)
+public <A extends java.lang.String> int C0.v4(int,scala.collection.immutable.List<Val<A>>)
 public scala.collection.immutable.List C0.v2()
 public <A> scala.collection.immutable.List<Val<A>> C0.v2()
 
@@ -14,9 +14,9 @@ public <A> java.lang.Object C1.v1(java.lang.Object)
 public java.lang.Object C1.v3()
 public <A> java.lang.Object C1.v3()
 public java.lang.Object C1.v4(java.lang.Object,scala.collection.immutable.List)
-public <A> java.lang.Object C1.v4(java.lang.Object,scala.collection.immutable.List<java.lang.Object>)
+public <A extends java.lang.String> java.lang.Object C1.v4(java.lang.Object,scala.collection.immutable.List<ValAny<A>>)
 public scala.collection.immutable.List C1.v2()
-public <A> scala.collection.immutable.List<java.lang.Object> C1.v2()
+public <A> scala.collection.immutable.List<ValAny<A>> C1.v2()
 
 C2
 public java.lang.String C2.v1(java.lang.String)
@@ -24,29 +24,29 @@ public <A> java.lang.String C2.v1(java.lang.String)
 public java.lang.String C2.v3()
 public <A> java.lang.String C2.v3()
 public java.lang.String C2.v4(java.lang.String,scala.collection.immutable.List)
-public <A> java.lang.String C2.v4(java.lang.String,scala.collection.immutable.List<java.lang.String>)
+public <A extends java.lang.String> java.lang.String C2.v4(java.lang.String,scala.collection.immutable.List<ValStr<A>>)
 public scala.collection.immutable.List C2.v2()
-public <A> scala.collection.immutable.List<java.lang.String> C2.v2()
+public <A> scala.collection.immutable.List<ValStr<A>> C2.v2()
 
 C3
 public java.lang.Object C3.v1(java.lang.Object)
-public A C3.v1(A)
+public java.lang.Object C3.v1(java.lang.Object)
+public java.lang.Object C3.v3()
 public java.lang.Object C3.v3()
-public A C3.v3()
 public java.lang.Object C3.v4(java.lang.Object,scala.collection.immutable.List)
-public A C3.v4(A,scala.collection.immutable.List<A>)
+public java.lang.Object C3.v4(java.lang.Object,scala.collection.immutable.List<ValA<A>>)
 public java.lang.Object C3.x()
 public A C3.x()
 public scala.collection.immutable.List C3.v2()
-public scala.collection.immutable.List<A> C3.v2()
+public scala.collection.immutable.List<ValA<A>> C3.v2()
 
 C4
 public java.lang.Integer C4.v1(java.lang.Integer)
-public int C4.v1(int)
+public java.lang.Integer C4.v1(java.lang.Integer)
+public java.lang.Integer C4.v3()
 public java.lang.Integer C4.v3()
-public int C4.v3()
 public java.lang.Integer C4.v4(java.lang.Integer,scala.collection.immutable.List)
-public int C4.v4(int,scala.collection.immutable.List<ValA<java.lang.Object>>)
+public java.lang.Integer C4.v4(java.lang.Integer,scala.collection.immutable.List<ValA<java.lang.Object>>)
 public scala.collection.immutable.List C4.v2()
 public scala.collection.immutable.List<ValA<java.lang.Object>> C4.v2()
 
@@ -56,29 +56,29 @@ public java.lang.String C4B.v1(java.lang.String)
 public java.lang.String C4B.v3()
 public java.lang.String C4B.v3()
 public java.lang.String C4B.v4(java.lang.String,scala.collection.immutable.List)
-public java.lang.String C4B.v4(java.lang.String,scala.collection.immutable.List<java.lang.String>)
+public java.lang.String C4B.v4(java.lang.String,scala.collection.immutable.List<ValA<java.lang.String>>)
 public scala.collection.immutable.List C4B.v2()
-public scala.collection.immutable.List<java.lang.String> C4B.v2()
+public scala.collection.immutable.List<ValA<java.lang.String>> C4B.v2()
 
 C5
 public double C5.f2(int,java.lang.Object,java.lang.String,double)
 public double C5.f2(int,java.lang.Object,java.lang.String,double)
 public int C5.f3(java.lang.Integer)
-public int C5.f3(int)
+public int C5.f3(java.lang.Integer)
+public int C5.f4(java.lang.Integer)
 public int C5.f4(java.lang.Integer)
-public int C5.f4(int)
 public int C5.f5(java.lang.Integer)
-public int C5.f5(int)
+public int C5.f5(java.lang.Integer)
 public java.lang.Object C5.f1(int,java.lang.Object,java.lang.String,java.lang.Object)
-public <A> A C5.f1(int,java.lang.Object,java.lang.String,A)
+public <A> java.lang.Object C5.f1(int,java.lang.Object,java.lang.String,java.lang.Object)
 
 C6
 public java.lang.Object C6.f1(int,java.lang.Object,java.lang.String,java.lang.Object)
-public A C6.f1(int,java.lang.Object,java.lang.String,A)
+public java.lang.Object C6.f1(int,java.lang.Object,java.lang.String,java.lang.Object)
 
 C7
 public java.lang.Integer C7.f1(int,java.lang.Object,java.lang.String,java.lang.Integer)
-public int C7.f1(int,java.lang.Object,java.lang.String,int)
+public java.lang.Integer C7.f1(int,java.lang.Object,java.lang.String,java.lang.Integer)
 public java.lang.Object C7.f1(int,java.lang.Object,java.lang.String,java.lang.Object)
 public java.lang.Object C7.f1(int,java.lang.Object,java.lang.String,java.lang.Object)
 
diff --git a/tests/disabled/reflect/run/t6344.scala b/tests/run/t6344.scala
similarity index 98%
rename from tests/disabled/reflect/run/t6344.scala
rename to tests/run/t6344.scala
index 6f82e4ba51c9..3742a9549f6a 100644
--- a/tests/disabled/reflect/run/t6344.scala
+++ b/tests/run/t6344.scala
@@ -1,3 +1,6 @@
+// scalajs: --skip
+// (JVM-only, generic signatures)
+
 import scala.reflect.{ClassTag, classTag}
 import java.lang.Integer